Figure 6. Effect of UVB on CHS in PAF-R chimeric mice.
Wild-type (BoyJ), PAF-R−/− , or two groups of chimeric mice with PAF-R-positive bone marrow in a PAF-R-negative host and PAF-R-negative bone marrow in a PAF-R-positive host or a transplantation control (PAF-R-positive bone marrow in a PAF-R-negative host) were treated with local irradiation with 0 (sham) or 7,500 J m−2 UVB. Mice were then sensitized to DNFB and elicitation reactions performed on the dorsal ears as outlined in Materials and Methods. At 24 hours after elicitation reactions, 5 mm punch biopsies were obtained from the ears and weighed. The data listed are the mean±SEM difference in ear biopsy weights. Parentheses indicate numbers of mice used in each treatment. *Statistically (P<0.05) significant changes.