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. Author manuscript; available in PMC: 2010 Mar 1.

Published in final edited form as: Inflamm Bowel Dis. 2009 Mar;15(3):341–352. doi: 10.1002/ibd.20753

Levels of 16 cytokines were measured simultaneously using a biometric multiplex assay from serum of mice induced with chronic DSS and TNBS-induced colitis. (A) Cytokine profiles in chronic colitis is represented by an enhanced pro-humoral cytokine profile in chronic DSS (IL-6, IFN-γ, and IL-4, IL-10), and a distinct cytotoxic and chemotactic cytokine profile in chronic TNBS (IL-12, IL-17, and MIP-1α). (B) Acute inflammation in DSS colitis converts to a predominant Th2-mediated inflammatory response in the chronic state (lower levels of TNFα, IL-17 and KC, and elevated levels of IL-4, and IL-10), but chronic TNBS colitis is characterized by an enhanced Th1-Th17 immune response (higher IL-12 and IL-17 levels). (C) Levels of other cytokines, including chemokines did not change significantly between the models.

Levels of 16 cytokines were measured simultaneously using a biometric multiplex assay from serum of mice induced with chronic DSS and TNBS-induced colitis. (A) Cytokine profiles in chronic colitis is represented by an enhanced pro-humoral cytokine profile in chronic DSS (IL-6, IFN-γ, and IL-4, IL-10), and a distinct cytotoxic and chemotactic cytokine profile in chronic TNBS (IL-12, IL-17, and MIP-1α). (B) Acute inflammation in DSS colitis converts to a predominant Th2-mediated inflammatory response in the chronic state (lower levels of TNFα, IL-17 and KC, and elevated levels of IL-4, and IL-10), but chronic TNBS colitis is characterized by an enhanced Th1-Th17 immune response (higher IL-12 and IL-17 levels). (C) Levels of other cytokines, including chemokines did not change significantly between the models.