Table 2.
Priority 1 (>99.9% confidence level) proteins that were significantly (p-values < 0.015; q-values < 0.25) different and changed by 15% or greater in the nucleus accumbens shell between the ethanol-injected (E) and control (C) alcohol-preferring (P) rats
| Protein_ID | Gene symbol | Annotation | PE/PC |
|---|---|---|---|
| IPI00207891.2 | 31_kDa protein | -1.17a | |
| IPI00562632.1 | 33_kDa_protein | 1.24b | |
| 15986733 | Rab4b | AF408432_1_GTP-binding_protein_RAB4_[Mus_musculus] | -1.20b |
| IPI00231118.4 | Calb1 | Calbindin | -1.17b |
| IPI00189995.1 | Calb2 | Calretinin | -1.24 |
| IPI00213015.1 | Dctn2 | Dynactin_2 | 1.18 |
| IPI00231733.6 | Gnai1 | Guanine_nucleotide-binding_protein_G(i),_alpha-1_subunit | 1.24a,b |
| 57829 | Nefh | heavy_neurofilament_polypeptide_(854_AA)_[Rattus sp.] | -1.17 |
| IPI00372709.3 | Igsf8 | immunoglobulin_superfamily,_member_8 | -1.18 |
| IPI00417225.1 | Synpo | Isoform_1_of_Synaptopodin | 1.16b |
| IPI00212566.3 | Syngap1 | Isoform_3_of_Ras_GTPase-activating_protein_SynGAP | -1.19 |
| 66857 | KIRTPR_pyruvate_kinase_(EC_2.7.1.40),_erythrocyte splice_form_R_-_rat | 1.23 | |
| IPI00471530.1 | Lap3 | Leucine_aminopeptidase_3 | 1.20 |
| IPI00231997.5 | Ndufa5 | NADH_dehydrogenase_[ubiquinone]_1_alpha_subcomplex subunit_5 | 1.17 |
| IPI00231641.4 | Pgm1 | Phosphoglucomutase-1 | 1.26a,b |
| IPI00369349.3 | Atp6v1e2 | PREDICTED:_similar_to_ATPase,_H+_transporting,_V1_subunit_E-like_2_isoform_2 | -1.15a |
| IPI00371946.3 | Marcks | PREDICTED:_similar_to_Myristoylated_alanine-rich_C-kinase_substrate | -1.37 |
| IPI00464820.4 | Ngef | PREDICTED:_similar_to_neuronal_guanine_nucleotide_exchange_factor | 1.65b |
| IPI00369480.3 | Otub1 | PREDICTED:_similar_to_OTU_domain,_ubiquitin_aldehyde_binding_1 | 1.24 |
| IPI00394488.2 | LOC498174 | Similar_to_NipSnap2_protein | 1.26b |
| IPI00201969.1 | Vat1 | Vesicle_amine_transport_protein_1_homolog | -1.15 |
| IPI00215349.3 | Wdr1 | WD_repeat_protein_1 | 1.18a,b |
PE/PC = fold change ethanol over control value; minus sign indicates that PC value was greater than PE value; n = 10 for PE and n = 9 for PC.
a
Similar ratio change found for NP rats;
b
similar ratio change observed for W rats. There were no values for PE/PC that changed in the opposite direction in NP or W rats.