Table 3.
Priority 1 (>99.9% confidence level) proteins that were significantly (p-values < 0.015; q-values < 0.06) different and changed by 15% or greater in the nucleus accumbens shell between the ethanol-injected (E) and control (C) alcohol-non-preferring (NP) rats
| Protein ID | Gene symbol | Annotation | NPE/NPC |
|---|---|---|---|
| IPI00231340.8 | 11_kDa_protein | 1.28 | |
| 225775 | rbcL | 1313192A_calmodulin_dependent_protein_kinase_II | 1.34 |
| IPI00362291.1 | 16_kDa_protein | -1.23b | |
| IPI00189519.1 | 19_kDa_protein | 1.28c | |
| IPI00188732.2 | 21_kDa_protein | 1.25 | |
| 1580888 | 2116232A_2-oxoglutarate_carrier_protein | 1.16 | |
| IPI00207891.2 | 31_kDa_protein | 1.26a | |
| IPI00782342.1 | 44_kDa_protein | -1.16 | |
| IPI00361239.4 | 49_kDa_protein | 1.33 | |
| IPI00200145.1 | Rplp1 | 60S_acidic_ribosomal_protein_P1 | -1.15 |
| IPI00231954.5 | Pfkp | 6-phosphofructokinase_type_C | 1.13 |
| 109966 | A35244_hexokinase_(EC_2.7.1.1),_tumor_-_mouse | 1.18 | |
| IPI00382300.3 | Rab1 | Ac2-048 | 1.21 |
| IPI00362072.2 | Actr2 | Actin-like_protein_2 | 1.15 |
| IPI00421909.3 | Spg3a | Atlastin-like_protein | 1.16 |
| IPI00196107.1 | Atp5f1 | ATP_synthase_B_chain,_mitochondrial_precursor | 1.20 |
| IPI00198620.1 | Atp5d | ATP_synthase_delta_chain,_mitochondrial_precursor | -1.21 |
| IPI00214665.2 | ATP-citrate_synthase | 1.34 | |
| IPI00193173.4 | Pcp4 | Brain-specific_polypeptide_PEP-19 | -1.35 |
| IPI00192337.1 | Camk2a | Calcium/calmodulin-dependent_protein_kinase_type_II_alpha_chain | 1.33 |
| IPI00231955.5 | Calm1 | Calmodulin | -1.28 |
| IPI00209824.2 | Camk2b | Calmodulin-dependent_protein_kinase_II_beta_M_isoform | 1.21 |
| IPI00215463.1 | Calml3 | Calmodulin-like_3 | -1.37 |
| 38014843 | Cd81 | Cd81_protein_[Rattus_norvegicus] | 1.21 |
| IPI00199076.2 | Pde2a | cGMP-dependent_3′,5′-cyclic_phosphodiesterase | 1.21 |
| 230824 | Grhl3 | Chain_,_Calmodulin | -1.31 |
| 29747871 | Csl | Citrate_synthase_like_[Mus_musculus] | 1.15 |
| IPI00193983.2 | Cltc | Clathrin_heavy_chain | 1.22 |
| 47605479 | Slc25a12 | CMC1_MOUSE_Calcium-binding_mitochondrial_carrier protein_Aralar1_(mitochondrial_aspartate_glutamate_carrier_1 | 1.23 |
| IPI00210978.1 | Cplx1 | Complexin-1 | -1.21 |
| 117104 | Cox5b | COX5B_MOUSE_Cytochrome_c_oxidase_polypeptide_Vb,_mitochondrial_precursor | -1.18 |
| IPI00188313.1 | Ckmt2 | Creatine_kinase,_sarcomeric_mitochondrial_precursor | 1.18 |
| IPI00192246.1 | Cox5a | Cytochrome_c_oxidase_polypeptide_Va,_mitochondrial_precursor | -1.18 |
| IPI00193918.1 | Cox5b | Cytochrome_c_oxidase_polypeptide_Vb,_mitochondrial_precursor | -1.17 |
| IPI00734686.2 | COII | cytochrome_c_oxidase_subunit_II | 1.31 |
| IPI00421955.1 | Ppp1r1b | Dopamine-and_cAMP-regulated_phosphoprotein_DARPP-32 | -1.27 |
| IPI00231407.4 | Dbn1 | drebrin_1 | -1.15 |
| IPI00231247.8 | Map2k1 | Dual_specificity_mitogen-activated_protein_kinase_kinase_1 | 1.17 |
| IPI00327630.1 | Dync1h1 | Dynein_heavy_chain,_cytosolic | 1.21 |
| IPI00195372.1 | Eef1a1 | Elongation_factor_1-alpha_1 | 1.15 |
| 119348 | Eno2 | ENOG_MOUSE_Gamma-enolase_(2-phospho-D-glycerate_hydro-lyase)_(Neural_enolase)_(Neuron-specific_enolase)_(NSE)_(Enolase_2) | -1.16 |
| IPI00422053.1 | Gna13 | Galpha13 | 1.23 |
| IPI00326412.3 | Eno2 | Gamma-enolase | -1.15 |
| IPI00364311.1 | Gpi | Glucose_phosphate_isomerase | 1.16 |
| IPI00191733.1 | Gad2 | Glutamate_decarboxylase_2 | 1.15 |
| IPI00199465.1 | Gls | Glutaminase_kidney_isoform,_mitochondrial_precursor | 1.18 |
| IPI00324020.5 | Glul | glutamine_synthetase_1 | 1.19 |
| IPI00231150.4 | GST | Glutathione_S-transferase_alpha_(Fragment) | 1.28 |
| IPI00287309.1 | Gpm6a | Glycoprotein_m6a | 1.17 |
| IPI00213685.1 | Rab3d | GTP-binding_protein_Rab-3D | 1.20 |
| IPI00230868.4 | Gnaq | guanine_nucleotide_binding_protein,_alpha_q_polypeptide | 1.15 |
| IPI00230866.6 | Gna12 | Guanine_nucleotide-binding_protein_alpha-12_subunit | 1.23 |
| IPI00231733.6 | Gnai1 | Guanine_nucleotide-binding_protein_G(i),_alpha-1_subunit | 1.22a,b |
| IPI00231925.7 | Gnai2 | Guanine_nucleotide-binding_protein_G(i),_alpha-2_subunit | 1.24 |
| IPI00202543.1 | Hk1 | Hexokinase-1 | 1.18 |
| IPI00231650.6 | Hist1h1c | Histone_H1.2 | 1.19b |
| IPI00188688.1 | H2a | Histone_H2a | 1.36 |
| IPI00231880.6 | H2afz | Histone_H2A.Z | 1.38 |
| IPI00368293.4 | Histh2a1 | Histone_H2A_type_1 | 1.30 |
| IPI00231475.6 | H3f3b | Histone_H3.3 | 1.36 |
| IPI00199273.1 | St13 | Hsc70-interacting_protein | -1.15 |
| IPI00205372.3 | Stxbp1 | Isoform_1_of_Syntaxin-binding_protein_1 | 1.20 |
| IPI00569103.3 | Mbp | Isoform_3_of_Myelin_basic_protein_S | 1.42 |
| IPI00196730.1 | Camk2g | Isoform_A_of_Calcium/calmodulin-dependent_protein_kinase_type_II_gamma_chain | 1.34 |
| IPI00212226.1 | Camk2d | Isoform_Delta_1_of_Calcium/calmodulin-dependent_protein_kinase_type_II_delta_chain | 1.35 |
| IPI00230956.1 | Slc1a3 | Isoform_GLAST-1A_of_Excitatory_amino_acid_transporter_1 | 1.24 |
| IPI00213663.1 | Slc1a2 | Isoform_Glt1_of_Excitatory_amino_acid_transporter_2 | 1.21 |
| IPI00188119.1 | Atp12a | Isoform_Long_of_Potassium-transporting_ATPase_alpha_chain_2 | 1.27 |
| IPI00205493.1 | Snca | Isoform_Syn1_of_Alpha-synuclein | -1.18 |
| IPI00197711.1 | Ldha | L-lactate_dehydrogenase_A_chain | 1.15 |
| IPI00231261.6 | Slc25a11 | Mitochondrial_2-oxoglutarate/malate_carrier_protein | 1.17 |
| IPI00231819.5 | Mbp1 | myelin_basic_protein_isoform_1 | 1.39 |
| IPI00231265.2 | Mbp4 | myelin_basic_protein_isoform_4 | 1.41 |
| IPI00421549.3 | Ndufa10 | NADH_dehydrogenase_(Ubiquinone)_1_alpha_subcomplex_10 | 1.15 |
| IPI00390362.1 | Ndufv3 | NADH_dehydrogenase_[ubiquinone]_flavoprotein_3,_mitochondrial_precursor | -1.19 |
| IPI00205396.1 | Ncdn | NORBIN | 1.15 |
| IPI00214262.1 | Nsfl1c | NSFL1_cofactor_p47 | -1.26 |
| IPI00230937.4 | Pebp1 | Phosphatidylethanolamine-binding_protein_1 | -1.20 |
| 9790051 | Pfkp | phosphofructokinase,_platelet_[Mus_musculus] | 1.15 |
| IPI00231641.4 | Pgm1 | Phosphoglucomutase-1 | 1.21a,b |
| 20141789 | Prdx5 | PRDX5_MOUSE_Peroxiredoxin-5,_mitochondrial_precursor_(Prx-V)_(Peroxisomal_antioxidant_enzyme)_(PLP)_(Thioredoxin_reductase) | -1.16 |
| IPI00212258.1 | Phpt | PREDICTED:_similar_to_14_kDa_phosphohistidine_Phosphatase | -1.21 |
| IPI00369349.3 | Atp6v1e2 | PREDICTED:_similar_to_ATPase,_H+_transporting,_V1_subunit_E-like_2_isoform_2 | -1.15a |
| IPI00208551.3 | 6720456B0 7Rik | PREDICTED:_similar_to_chromosome_3_open_reading_frame_10 | -1.15 |
| IPI00200624.1 | H2afj | PREDICTED:_similar_to_H2A_histone_family,_member_J | 1.36 |
| IPI00767428.1 | H3f2 | PREDICTED:_similar_to_H3_histone,_family_2_isoform_2 | 1.38 |
| IPI00566481.2 | Hist1h2ac | PREDICTED:_similar_to_histone_2,_H2ac | 1.30 |
| IPI00209163.1 | Hist1h2be | PREDICTED:_similar_to_histone_2,_H2be | 1.17 |
| IPI00764762.1 | Hist1h2a | PREDICTED:_similar_to_histone_2a | 1.43 |
| IPI00369397.5 | H2afx | PREDICTED:_similar_to_Histone_H2A.x | 1.31 |
| IPI00365775.3 | Me3 | PREDICTED:_similar_to_malic_enzyme_3,_NADP(+)-dependent,_mitochondrial | 1.26 |
| IPI00358441.1 | Ndufa9 | PREDICTED:_similar_to_NADH_dehydrogenase_(ubiquinone)_1_alpha_subcomplex,_9 | 1.20 |
| IPI00569808.2 | Nav3 | PREDICTED:_similar_to_neuron_navigator_3 | -1.30 |
| IPI00191897.4 | Nme2 | PREDICTED:_similar_to_Nucleoside_diphosphate_kinase_B | -1.15 |
| IPI00365705.6 | Atp1a1 | PREDICTED:_similar_to_Potassium-transporting_ATPase_alpha_chain_1 | 1.45 |
| IPI00207725.3 | Pnp | PREDICTED:_similar_to_purine-nucleoside_phosphorylase | 1.15 |
| IPI00388687.3 | Slc25a12 | PREDICTED:_similar_to_solute_carrier_family_25_(mitochondrial_carrier,_Aralar),_member_12 | 1.27 |
| IPI00189416.2 | Tpt1 | PREDICTED:_similar_to_tumor_protein,_translationally-controlled_1 | -1.17 |
| IPI00199600.1 | PREDICTED:_similar_to_vacuolar_H+_ATPase_G1 | -1.24 | |
| 50489 | CD207 | pro-alpha-2(I)_collagen_[Mus_musculus] | -1.25 |
| IPI00190557.2 | Phb2 | Prohibitin-2 | 1.20 |
| IPI00201797.1 | Prkcg | Protein_kinase_C_gamma_type | 1.17 |
| IPI00194324.1 | Pdhb | Pyruvate_dehydrogenase_E1_component_subunit_beta,_mitochondrial_precursor | -1.18 |
| IPI00555185.1 | Rab10 | RAB10,_member_RAS_oncogene_family | 1.21 |
| 6093900 | Rab3b | RAB3B_RAT_Ras-related_protein_Rab-3B | 1.19 |
| IPI00325762.1 | Rab3a | Ras-related_protein_Rab-3A | 1.21 |
| IPI00209150.1 | Rab3c | Ras-related_protein_Rab-3C | 1.16 |
| IPI00187747.1 | Rap1a | Ras-related_protein_Rap-1A_precursor | 1.25 |
| 631898 | Unc18 | S39345_unc-18_protein_homolog,_67K_-_rat | 1.20 |
| IPI00326305.3 | Atp1a1 | Sodium/potassium-transporting_ATPase_alpha-1_chain_precursor | 1.21 |
| IPI00205693.1 | Atp1a2 | Sodium/potassium-transporting_ATPase_alpha-2_chain_precursor | 1.23 |
| IPI00231451.4 | Atp1a3 | Sodium/potassium-transporting_ATPase_alpha-3_chain | 1.23 |
| IPI00231643.4 | Sod1 | Superoxide_dismutase | -1.17 |
| IPI00208115.4 | Sv2a | Synaptic_vesicle_glycoprotein_2A | 1.28 |
| IPI00324381.5 | Stx1a | Syntaxin-1A | 1.23 |
| IPI00188956.1 | Thy1 | Thy-1_membrane_glycoprotein_precursor | 1.18 |
| IPI00230925.4 | Tmsb4x | Thymosin_beta-4 | -1.21 |
| IPI00362927.1 | Tuba4a | Tubulin,_alpha_4 | 1.24 |
| IPI00189795.1 | Tuba1a | Tubulin_alpha-1_chain | 1.23 |
| IPI00339167.4 | Tuba1b | Tubulin_alpha-2_chain | 1.24 |
| IPI00369093.1 | Uqcrh | Ubiquinol-cytochrome_c_reductase_complex_11_kDa protein,_mitochondrial_precursor | -1.23 |
| 12847763 | Hist1h4i | unnamed_protein_product_[Mus_musculus] | 1.31 |
| 26337455 | Hdgfrp3 | unnamed_protein_product_[Mus_musculus] | -1.35 |
| IPI00364780.2 | Atp6v1h | Vacuolar_ATPase_subunit_H | 1.16 |
| IPI00198327.2 | Vdac2 | Voltage-dependent_anion-selective_channel_protein_2 | 1.28 |
| IPI00213598.1 | Wasf1 | WAS_protein_family,_member_1 | 1.19 |
| IPI00215349.3 | Wdr1 | WD_repeat_protein_1 | 1.19a,b |
| 33468975 | Zic5 | zinc_finger_protein_of_the_cerebellum_5_[Mus_musculus] | -1.27 |
NPE/NPC = fold change ethanol over control value; minus sign indicates that NPC value was greater than NPE value; n = 10 for NPE and n = 10 for NPC.
a
Similar ratio change found for P rats;
b
similar ratio change observed for W rats;
c
opposite ratio change found for W rats.