. Author manuscript; available in PMC: 2010 Apr 1.

Published in final edited form as: J Affect Disord. 2008 Aug 8;114(1-3):50–57. doi: 10.1016/j.jad.2008.07.003

Table 2.

Relationship between diagnosis and temporal lobe volume adjusted for cerebral volume

Temporal lobe measure	Mean adjusted volume ratio (SD)		F value	p-value
	Bipolar subjects	Control subjects
Left hemisphere
Gray matter	0.0506 (0.0042)	0.0513 (0.0037)	0.66	0.4188
White matter	0.0202 (0.0023)	0.0193 (0.0022)	11.88	0.0007
Total (Gray + White)	0.0708 (0.0049)	0.0706 (0.0048)	1.37	0.2428

Right hemisphere
Gray matter	0.0515 (0.0040)	0.0515 (0.0039)	0.43	0.5113
White matter	0.0205 (0.0025)	0.0193 (0.0024)	15.19	0.0001
Total (Gray + White)	0.0720 (0.0051)	0.0708 (0.0052)	5.15	0.0243
Total cerebral white matter	0.3446 (0.0485)	0.3492 (0.0428)	0.02	0.8992

Models examined for the effect of diagnosis on adjusted temporal lobe volumes while controlling for age, sex, education, and race. The diagnosis variable had 1, 211 degrees of freedom. Only white matter measures remained statistically significant after correcting for multiple comparisons.