Table 3.
Psychotropic medication use and temporal lobe white matter volumes
| On Drug | Off Drug | t value | P value | |
|---|---|---|---|---|
| Lithium | N = 39 | N = 173 | ||
| Left temporal WM | 0.0202 (0.0020) | 0.0197 (0.0024) | 1.01 | 0.3119 |
| Right temporal WM | 0.0204 (0.0022) | 0.0200 (0.0026) | 0.95 | 0.3408 |
|
| ||||
| Antipsychotics | N = 41 | N = 171 | ||
| Left temporal WM | 0.0210 (0.0025) | 0.0195 (0.0022) | 3.70 | 0.0003 |
| Right temporal WM | 0.0214 (0.0024) | 0.0193 (0.0024) | 3.92 | 0.0001 |
|
| ||||
| Anticonvulsants | N = 65 | N = 147 | ||
| Left temporal WM | 0.0202 (0.0024) | 0.0196 (0.0022) | 1.68 | 0.0949 |
| Right temporal WM | 0.0206 (0.0026) | 0.0198 (0.0024) | 2.17 | 0.0322 |
|
| ||||
| Antidepressants | N = 55 | N = 157 | ||
| Left temporal WM | 0.0199 (0.0021) | 0.0198 (0.0024) | 0.21 | 0.8341 |
| Right temporal WM | 0.0201 (0.0022) | 0.0200 (0.0026) | 0.08 | 0.9340 |
|
| ||||
| Benzodiazepines | N = 44 | N = 168 | ||
| Left temporal WM | 0.0202 (0.0024) | 0.0197 (0.0023) | 1.28 | 0.2032 |
| Right temporal WM | 0.0202 (0.0025) | 0.0200 (0.0025) | 0.51 | 0.6129 |
Results of two-tailed t-tests examining associations between adjusted regional volumes and psychotropic medication use, with 210 degrees of freedom. Only white matter results are shown. α = 0.00125 after Bonferroni correction for multiple comparisons (standard α = 0.05 divided by 40 separate comparisons).