Table 4.
Adjusted temporal lobe white matter volume differences: relationship with diagnosis and antipsychotic medication use
| Least squares mean adjusted volume | p-value between groups | ||||
|---|---|---|---|---|---|
| Bipolar subjects on antipsychotics | Bipolar subjects not on antipsychotics | Control subjects | 1–2 | 1–3 | 2–3 |
| (Group 1)
N = 41 |
(Group 2)
N = 84 |
(Group 3)
N = 87 |
|||
|
Left hemisphere temporal lobe white matter, adjusted for cerebrum | |||||
| 0.0214 | 0.0202 | 0.0195 | 0.0212 | <0.0001 | 0.0888 |
|
| |||||
| Right hemisphere temporal lobe white matter, adjusted for cerebrum | |||||
| 0.0217 | 0.0205 | 0.0196 | 0.0211 | <0.0001 | 0.0358 |
|
| |||||
| Right hemisphere temporal lobe total volume, adjusted for cerebrum | |||||
| 0.0731 | 0.0713 | 0.0703 | 0.4026 | 0.0114 | 0.1518 |
Temporal lobe white matter volumes are adjusted for cerebral volume, resulting from models also controlling for age, sex, education, and race. P-values determined using the least square means procedure, adjusted for multiple comparisons using the Tukey-Kramer procedure.