Fig. 9. Dox-induced caspase activation is TAK1-dependent.
A. H11/HspB8 transfected A2058 cells were transfected with FLAG-K63W or empty vector, treated (or not) with Dox and immunoblotted with antibodies to caspase-3, FLAG or actin. B. Procaspase-3 levels standardized to actin are expressed as fold-decrease relative to untreated cells.