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(a) Schematic depiction of place-exchange between native cationic ligands and cellular glutathione (GSH) on nanoparticle surface. (b) Elevation in transfection level depending on dose of glutathione monoester (GSH–OEt). Cells were preincubated with GSH–OEt for 1 h then washed prior to transfection. (c) Decrease in transfection efficiency upon BSO treatment. Cells were plated in BSO-containing (2 mM) media and incubated for 24 h.
