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. Author manuscript; available in PMC: 2009 Feb 17.
Published in final edited form as: Cancer Cell. 2008 Mar;13(3):206–220. doi: 10.1016/j.ccr.2008.01.034

Figure 7. HIF-1 Is a Critical Regulator of BMDC Recruitment in Tumors.

Figure 7

Hypoxia in tumors increases HIF1, which, partly by inducing VEGF and SDF1α in tumor cells, recruits BMDC including EPC, PPC, and CD45+ monocytic vascular modulatory cells to endorse vascular remodeling in glioblastomas. SDF1α serves as a retention factor of CXCR4+ vascular progenitor and monocytic BMDC in GBM. HIF1 not only induces VEGF transcription in GBM, but also increases VEGF activity by recruiting CD45+ BMDC that carry and secrete MMP-9 to the tumor site, which in turn makes sequestered VEGF bioavailable for its receptor VEGFR2.