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. 2009 Mar 13;5(3):e1000305. doi: 10.1371/journal.pcbi.1000305

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Arora, Dixit.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The expected waiting time for the emergence of (A) genomes with different numbers of resistance mutations for different n when E = 0, (B) the corresponding n ^th mutants as a function of E, (C) quintuple mutants when n = 5 as a function of the crossover frequency (ρl), for E = 0.005 (green), 0 (red), −0.005 (blue). The inset in (C) shows the corresponding reduction in the time of emergence, 1−W(ρl)/W(ρl = 0). (D) Model predictions of emergence (filled symbols) and fixation (open symbols) times of double mutants when n = 2 and E = 0.05 (green), 0 (red), −0.05 (blue). In (A) to (C), we let ε₀ = 0.85 and ε_n = 0.25, whereas in (D) ε₀ = 0.1 and ε_n = 0. All the other parameters are identical to those in Figure 4.