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. 2009 Feb 20;284(8):5343–5351. doi: 10.1074/jbc.M808430200

FIGURE 6.

FIGURE 6.

USP12/UAF1 and USP46/UAF1 complexes do not regulate FANCD2 ubiquitination or the FA pathway. A, immunoblot analysis of protein lysates prepared from stable HeLa cell lines expressing shRNA constructs targeting UAF1, USP1, USP12, or USP46. The lysates were analyzed using the indicated antibodies. B, model for various deubiquitinating complexes. The USP1/UAF1, USP12/UAF1, and USP46/UAF1 complexes are shown schematically as indicated. The speculated protein complexes containing other human deubiquitinating enzymes and their activating subunits are shown on the right.