TABLE 1.

Accessible surface area of SERCA transmembrane region

Crystallographic data used for ASA calculations (26, 27) were taken from the following: 2ear (1), 1iwo (3), 1su4 (2), 1vfp (4), and 3ba6 and 3b9b (5). Tg means thapsigargin; AMPPCP means adenosine 5′-(β,γ -methylene)triphosphate.

Crystal structure	Condition	ASA	Relative hydrophobicity	Conformation
		Å2	%
2ear	Tg + EGTA	8701	100	E2
1iwo	Tg + EGTA	8235	94.6	E2
3b9b	BeF4-	8164	93.8	E2
1su4	Ca2+	7114	81.7	E1
1vfp	Ca2+ + AMPPCP	7295	83.8	E1
3ba6	E1PCa	7350	84.5	E1