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. 2008 Dec 24;16(2):156–162. doi: 10.1128/CVI.00403-08

FIG. 2.

FIG. 2.

IgG antibody responses to fHbp v.1 (white bars) or fHbp v.2 (gray bars) as measured by ELISA. All native OMV vaccines were from LpxL1 KO mutants. (A) Responses to individual vaccines. Mutant H44/76, OMV vaccine with overexpressed fHbp in the v.1 group; Mutant NZ98/254, OMV vaccine with endogenous fHbp v.1 and heterologous fHbp v.2; Control NZ98/254, OMV vaccine with endogenous fHbp in the v.1 group; Recombinant v.2, recombinant fHbp v.2 encoded by the gene from strain 8047; Al(OH)3, control (used as the adjuvant for OMV and recombinant protein vaccines). (B) Responses to vaccine mixtures. MNM-OMV, native OMV from H44/76 and NZ98/254 mutants with fHbp v.1 and v.2; Recombinant v.1+v.2, recombinant fHbp v.1 and v.2; Detergent OMV WT H44/76 + NZ98/254, detergent-treated OMV from the respective wild-type strains. SE, standard error.