Time to culling for all reasons among mild- and severe-CM case cows. dimsurv, DIM of survival during lactation. Mild-CM case cows (grade M, solid line), severe-CM case cows (grade S, dashed line). A significantly greater hazard of culling for all reasons was shown among cows with one or two severe cases of CM, using time-to-event analysis and log-rank and Wilcoxon tests, P < 0.002.