TABLE 4.

Significant factors associated with change in daily milk production from 14 days before the onset to 21 days following the end of treatment for CM^a

Parameterb	Estimated PRODDIFF (lb/kg) (SE)c	t value	P value
Intercept	4.2/1.9 (9.37)	0.45	0.6560
J5 Vacc	−7.7/−3.5 (7.10)	−1.08	0.2859
DIM	−0.3/−0.1 (0.06)	−5.04	<0.0001
E. coli	−48.0/−21.8 (14.85)	−3.23	0.0025
J5 Vacc*E. coli	43.8/19.9 (17.80)	2.46	0.0185
CALV IGG1	13.4/6.1 (6.93)	1.93	0.0607
MAST IGG1	21.3/9.7 (7.99)	2.67	0.0112

^aData from a linear regression model of significant factors associated with the change in daily milk production from 14 days before the onset of CM to 21 days following the end of treatment (PRODDIFF).

^bJ5 Vacc, effect on PRODDIFF following CM of being vaccinated with J5; DIM, effect of each 1-day increase in DIM at onset of CM; E. coli, effect on PRODDIFF of being infected with E. coli; J5 Vacc*E. coli, effect on PRODDIFF of E. coli infection in J5 vaccinates compared with E. coli in controls; CALV IGG1, effect of J5-specific IgG1 antibody postcalving with OD values from 0.3 to 1.0 compared with higher or lower OD values for IgG1; MAST IGG1, effect of J5-specific IgG1 antibody after CM with OD values of ≤1.0 compared with higher OD values for IgG1. Overall linear regression model R², 0.61, P < 0.0001.

^cEstimated effects on PRODDIFF following CM, shown in lb and kg.