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Ras1 palmitoylation is required for pathogenesis in a murine model of cryptococcosis. The wild-type H99, ras1 mutant (CBN45), ras1 plus ras1(C203S, C204S) (CBN65A), ras1 plus ras1(C203S, C204S) (CBN71), and ras1 plus RAS1 reconstituted (CBN64) strains were intranasally inoculated into A/Jcr mice. Animal survival was monitored for 50 days.
