FIG. 4.

Depletion of complement results in virulence of the high-level C3-binding S. pneumoniae carriage isolate. The percentage of animals treated with CoVF that developed middle ear infection following intranasal challenge with a carriage isolate is shown. The control group included animals with an intact complement system (no CoVF treatment). * indicates that all four animals in the CoVF-treated group developed bacteremia and had to be euthanized, which precluded further middle ear sampling. ** signifies a P value of 0.007.