FIG. 6.

Association between IgG antibody responses to merozoite antigens and protection against symptomatic P. falciparum malaria. Children were stratified into groups of low, moderate, and high responders (based on tertiles) in order to test for associations between antibody responses and risk of symptomatic malaria (defined as parasitemia of >5,000 parasites/μl and fever). Values represent AHRs ± 95% confidence intervals, adjusted for spatial confounders (SC) (attendance at Mugil school and living 1 km from seaboard) or age and SC. Open circles, AHRs for medium versus low responders; filled circles, AHRs for high versus low responders. *, P < 0.05; **, P < 0.01; ***, P < 0.001. The 3D7 allele of MSP1-19 and AMA-1 was used.