TABLE 1.
Demographic, radiological, and microbiological data of patients suffering from aspergillosis
Patient | Gender | Underlying conditiona | Aspergillosis diagnosis | Prophylaxis | HRCT | GM | PCR resulte | Days before HRCTf | Days before GMg |
---|---|---|---|---|---|---|---|---|---|
1 | Male | ALL | Provenb | Fluconazole/itraconazole | Positive | Positive | Positive | 67 | 65 |
2 | Male | NHL | Probable | None | Positive | Positive | Positive | 0 | 0 |
3 | Female | AML | Probable | Itraconazole | Positive | Positive | Positive | −27 | −28 |
4 | Female | AML | Probable | Itraconazole | Positive | Positive | Positive | 61 | 199 |
5 | Female | MM | Probable | Fluconazole | Negativec | Positive | Positive | 0 | 0 |
6 | Male | AML | Probable | Itraconazole | Positive | Positive | Positive | 1 | 37 |
7 | Male | ALL | Probable | Itraconazole | Positive | Negatived | Positive | 84 | 79 |
8 | Female | AML | Probable | Itraconazole | Positive | Positive | Positive | 19 | 107 |
9 | Male | ALL | Probable | Itraconazole | Positive | Positive | Positive | 90 | 154 |
10 | Female | AML | Probable | Itraconazole | Positive | Positive | Negative | NCh | NC |
11 | Male | MDS | Possible | Itraconazole | Positive | Negative | Positive | −69 | NC |
12 | Male | AML | Possible | Itraconazole | Positive | Negative | Positive | 8 | NC |
ALL, acute lymphoblastic leukemia; NHL, non-Hodgkin's lymphoma; AML, acute myeloblastic leukemia; MM, multiple myeloma; MDS, myelodysplasic syndrome.
Proven aspergillosis by positive culture from tissue biopsies.
Patient was diagnosed with sinonasal aspergillosis after imaging showing sinusitis.
Patient was diagnosed by sputum culture with A. fumigatus.
The table includes analysis taking into account only two or more positive PCR results.
Time in days taken by the PCR-based technique to detect Aspergillus DNA before signs appeared on HRCT; a minus sign indicates that fungal DNA was detected later than signs on the HRCT.
Time in days taken by the PCR-based technique to detect Aspergillus DNA before the GM test was positive; a minus sign indicates that fungal DNA was detected after the GM test was positive. For patient 7, the calculation was made using the date the sputum culture was positive.
NC, not calculated. Values were not calculated because the test was negative.