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. 2008 Dec 17;83(5):2349–2356. doi: 10.1128/JVI.00821-08

TABLE 3.

Theoretical impact of an anti-Nef drug on VL, from a simulated population study

CSa ASb RFc ICA ΔlogVL
Mean SE
1 1 1.0 5.6 0.0021 0.0034
1 1 0.5 5.6 0.18 0.0083
1 1 0.5 1.0 0.18 0.0074
1 2 1.0 5.6 1.29 0.50
1 2 0.5 5.6 1.37 0.53
1 2 0.5 1.0 0.18 0.0078
2 1 1.0 5.6 0.62 0.17
2 1 0.5 5.6 1.20 0.18
2 1 0.5 1.0 0.63 0.021
2 2 1.0 5.6 1.81 0.84
2 2 0.5 5.6 2.4 0.81
2 2 0.5 1.0 0.63 0.022
a

CTL scenario: 1, DM; 2, DK.

b

Activation scenario: 1, downregulation of killing only; 2, downregulation also of activation in memory cells.

c

Replication factor (multiplies R0 in the Nef-defective strain).