TABLE A2.
Parameters in the in vivo CD8 modelb
| Parameter | Symbol | Value (for rates, per day) |
|---|---|---|
| Resting activation | α | (2-5) × 10−10 |
| NR “immigration” | β | See text |
| NR death rate | δNR | 0.00017 |
| MR death rate | δMR | 0.00017 or 0.333 |
| CTL death rate | δCTL | 0.333 |
| Reversion fraction | Revert | 0.05 |
| No. of doublings | ηd | 8 |
| Naïve cell cycles/day | 2.0 | |
| Memory cell cycles/day | 4.0 | |
| Naïve cell cycles before ES | 4 | |
| Memory cell cycles before ES | 1 | |
| Memory speed-up factor | 7.0 |
Defined quantities: NR, naïve resting cells; MR, memory resting cells; ηd, number of programmed-proliferation divisions; ES, effector status.