FIG. 2.

Binding of herpesvirus glycoproteins to host receptors during viral entry induces cytoskeletal rearrangements inside the cell. Binding of PRV gD to nectin-1 on the surfaces of swine trigeminal ganglion neurons activates certain Rho GTPase and mitogen-activated protein kinase (MAPK) signaling pathways, leading to the formation of varicosities/synaptic boutons. This event may prime neurons for egress of progeny virus particles. The attachment of KSHV gB to α3β1 integrin during viral entry activates RhoA and Rac1 GTPases, leading to the acetylation (stabilization) of microtubules and increased delivery of viral capsids to the nucleus.