TABLE 1.
Fold change of infected versus mock-infected corneas of selected inflammation-associated genes and ISGs
| Gene | Description | Fold changea in gene expression
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control 129 mice
|
Stat1−/− mice
|
||||||||||||
| WT virus
|
Δvhs virus
|
WT virus
|
Δvhs virus
|
||||||||||
| 1 dpi | 2 dpi | 3 dpi | 1 dpi | 2 dpi | 3 dpi | 1 dpi | 2 dpi | 3 dpi | 1 dpi | 2 dpi | 3 dpi | ||
| Acute-phase response proteins | |||||||||||||
| IL-1α | Interleukin-1α | 1.23 | 3.47 | 2.28 | 1.64 | 3.03 | 1.33 | -1.12 | 1.54 | 1.94 | 1.04 | 2.90 | 2.60 |
| IL-1β | Interleukin-1β | 4.20 | 5.36 | 4.74 | 5.47 | 1.84 | 1.54 | 1.42 | 36.35 | 87.96 | 1.58 | 68.31 | 69.09 |
| IL-6 | Interleukin-6 | 3.08 | 2.33 | 1.30 | 1.05 | 1.19 | -1.47 | 1.00 | 77.37 | 82.52 | 1.00 | 43.36 | 14.58 |
| TNF-α | Tumor necrosis factor alpha | 1.32 | 1.72 | 1.36 | -1.09 | 1.26 | 1.32 | 1.20 | 2.10 | 1.97 | 1.17 | 2.30 | 1.76 |
| Chemokines | |||||||||||||
| CCL2 | Chemokine (C-C motif) ligand 2; MCP-1 | 11.03 | 8.95 | 3.65 | 5.30 | 3.44 | 1.80 | 1.81 | 12.69 | 16.78 | 1.66 | 15.89 | 12.93 |
| CCL3 | Chemokine (C-C motif) ligand 3; MIP-1α | 1.68 | 2.42 | 2.14 | 4.48 | 2.38 | 1.55 | 1.21 | 6.80 | 27.74 | 1.50 | 4.81 | 24.16 |
| CCL4 | Chemokine (C-C motif) ligand 4; MIP-1β | 4.36 | 10.01 | 4.03 | 8.40 | 3.00 | 1.35 | 1.02 | 16.08 | 94.21 | -1.20 | 25.52 | 89.70 |
| CCL5 | Chemokine (C-C motif) ligand 5; RANTES | 2.54 | 10.40 | 3.52 | 1.85 | 4.64 | 1.50 | -1.58 | 2.30 | 17.74 | -1.45 | 4.47 | 23.49 |
| CCL12 | Chemokine (C-C motif) ligand 12; MCP-5 | 3.73 | 3.05 | 1.01 | 2.65 | 1.77 | -1.07 | -1.36 | 4.85 | 15.52 | 1.00 | 10.77 | 15.48 |
| CXCL1 | Chemokine (C-X-C motif) ligand 1; KC | 3.01 | 1.52 | 1.44 | 3.43 | 1.04 | 1.68 | 1.62 | 20.32 | 24.24 | 1.22 | 34.87 | 6.35 |
| CXCL2 | Chemokine (C-X-C motif) ligand 2; MIP-2α | 1.11 | 1.32 | -1.07 | -1.37 | 1.13 | 1.64 | 1.07 | 2.48 | 6.00 | 1.11 | 3.15 | 6.44 |
| CXCL9 | Chemokine (C-X-C motif) ligand 9 | 6.28 | 39.75 | 8.63 | 2.22 | 18.02 | 2.85 | 1.00 | -1.46 | 8.72 | 1.00 | 1.65 | 6.76 |
| CXCL10 | Chemokine (C-X-C motif) ligand 10; IP-10 | 65.08 | 53.83 | 8.64 | 40.54 | 10.00 | 2.76 | 1.00 | 78.95 | 571.37 | 1.00 | 187.94 | 520.68 |
| IFNs and ISGs | |||||||||||||
| IFN-α | Alpha interferon | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.03 | 0.00 | 11.88 | 2.11 |
| IFN-β | Beta interferon | 1.54 | 1.73 | -1.39 | 1.00 | -1.01 | -1.24 | 1.00 | 5.31 | 12.26 | -1.08 | 13.47 | 4.74 |
| IFN-γ | Gamma interferon | 2.41 | 8.17 | 1.16 | -1.15 | 2.39 | 1.14 | -1.24 | 6.70 | 5.60 | 1.00 | 13.27 | 10.96 |
| IFIT1 | IFN-induced protein with tetratricopeptide repeats 1 | 3.89 | 10.14 | 8.48 | 2.83 | 9.15 | 8.74 | -1.05 | 5.12 | 40.49 | -1.01 | 10.64 | 47.12 |
| ISG15 | ISG15 ubiquitinlike modifier; G1p2 | 2.09 | 6.14 | 8.21 | 1.73 | 6.44 | 7.72 | -1.07 | 2.24 | 14.42 | -1.14 | 4.47 | 15.15 |
a
That is, the fold change compared to mock-infected corneas. Italicized numbers indicate genes that did not meet the criteria of being at least twofold changed compared to mock-infected corneas (P ≤ 0.01). Boldface entries indicate genes that changed at least 10-fold compared to mock-infected corneas (P ≤ 0.01).