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. 2008 Dec 10;83(5):2130–2139. doi: 10.1128/JVI.02127-08

FIG. 7.

FIG. 7.

Preexisting Ab against Ad effectively prevent vector spillover from the site of injection in the tumor to the liver and lungs. Livers (a) and lungs (b) were collected from immunized and nonimmunized hamsters 7 and 13 days after the first i.t. injection. The tissues were homogenized in PBS, and DNA was isolated and quantified by PicoGreen assay. Real-time PCR with primers against INGN 007 was performed. This subexperiment is an arm of the experiment shown in Fig. 2 and 3. (c) Liver TCID50 titers 36 days after the first i.t. injection. This subexperiment is an arm of the experiment shown in Fig. 5 and 6. P = 0.0006 for NonImm+CP+007 versus Imm+CP+007 groups. sac, sacrifice.