FIG. 5.

Distribution of retroviral integrations according to the delta CpG index. The genes were classified according to their delta CpG index and represented as the sum of the distributions of the gene (in percentages) when moving from the most negative to the most positive delta CpG index. A similar classification was performed for the retroviral integrations of FV, MLV, HIV, and PERV (ASLV [not represented on the figure] displayed the same profile as FV). Integrations present in hot spots were also plotted separately for each data set (hot-spot curves). For all of the viruses except FV, a shift of the curve toward a higher delta CpG index was observed for the integrations present in hot spots (P < 0.005). The curve for the genes (noted RefSeq) is completely overlaid by the HIV integration curve and is not apparent. The retroviral integration datasets used are listed in Table S2 in the supplemental material.