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. 2008 Nov 26;83(4):1920–1929. doi: 10.1128/JVI.00856-08

FIG. 8.

FIG. 8.

Simulation of the delta CpG index distribution of integrations obtained with either MseI or AvrII/NheI. PERV integration profiles were simulated based on the use of either MseI or AvrII/NheI. The profiles obtained had to be similar to the one obtained for the PERV. Rb1 is a profile with a distribution of integrations of 39% CpG, 34% TSS, and 44% RefSeq; Rb2 is a profile with a distribution of integrations of 60% CpG, 40% TSS, and 44% RefSeq. Both MseI profiles (Rb1 MseI and Rb2 MseI) displayed a more rapid accumulation of simulated integration in the low-delta-CpG area than the distribution of the genes (dark blue line) or the accumulation of simulated integration with AvrII/NheI profiles (Rb1 AvrII/NheI and Rb2 AvrII/NheI) (P < 0.005).