TABLE 1.
Comparison of serum liver enzyme activities prior to experimental WHV infection and at the time of maximum acute liver injury following infection
| Woodchuck | Level of viremia | Serum liver enzyme activity (IU/liter)a
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| ALP | ALT | AST | GGT | ||||||
| F3538 | High | 4 | 7 | 4 | 39 | 46 | 296 | 3 | 3 |
| F3539 | High | 11 | 4 | 5 | 62 | 30 | 317 | 5 | 62 |
| F3524 | Intermediate | 3 | 6 | 4 | 62 | 70 | 498 | 5 | 6 |
| M3540 | Low | 6 | 5 | 4 | 4 | 41 | 50 | 3 | 3 |
| F3991 | Low | 6 | 5 | 4 | 13 | 14 | 41 | 3 | 3 |
| M3553 | Low | 17 | 30 | 4 | 9 | 24 | 56 | 3 | 3 |
a
The first value in each column was determined prior to experimental WHV infection at week zero. The second value was determined at the time of maximum serum SDH activity as a marker of acute liver injury. Peak serum SDH activities varied between woodchucks and were detected at 4 weeks postinfection in woodchuck M3540, at 5 weeks postinfection in woodchucks F3991 and M3553, at 10 weeks postinfection in woodchuck F3524, and at 12 weeks postinfection in woodchucks F3538 and F3539 (Fig. 1).