TABLE 3.
Comparison of hepatocyte proliferation, apoptosis in hepatocytes, and liver inflammation prior to experimental WHV infection and at the time of maximum acute liver injury following infection
| Woodchuck | Level of viremia | Liver proliferation, apoptosis, and inflammation (%)a
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| PCNA
|
Apoptosis
|
CD3+ cells
|
Macrophages
|
||||||
| 2 wk preinfection | Max serum SDH activity | 2 wk preinfection | Max serum SDH activity | 2 wk preinfection | Max serum SDH activity | 2 wk preinfection | Max serum SDH activity | ||
| F3538 | High | 0.9 | 11.0 | 0.5 | 2.0 | 9.7 | 85.0 | 0.6 | 13.7 |
| F3539 | High | 0.9 | 2.6 | 0 | 0.3 | 8.8 | 67.7 | 5.3 | 8.8 |
| F3524 | Intermediate | 0.5 | 8.2 | 0.5 | 1.4 | 10.7 | 48.9 | 2.3 | 16.7 |
| M3540b | Low | 0.8 | 1.7 | 0.5 | 0.8 | 11.7 | 9.7 | 5.1 | 2.1 |
| F3991 | Low | 0 | 0.2 | 0 | 0 | 35.5 | 46.0 | 26.4 | 10.0 |
| M3553 | Low | 0.5 | 0.8 | 0 | 0.2 | 40.0 | 36.5 | 12.9 | 16.3 |
a
The first value in each column was determined for hepatic specimens obtained 2 weeks prior to experimental WHV infection. The second value was determined for hepatic specimens obtained at or around the time of maximum serum SDH activity (see Tables 1 and 2 for details).
b
Maximum SDH activity for woodchuck M3540 was at 4 weeks postinfection, whereas the presented data were derived from using liver tissue obtained 4 weeks later (i.e., at 8 weeks postinfection).