FIG. 5.

Differential features of Polμ^−/− embryo DJ_H joints. (A) Frequencies of N⁺ DJ_H joints (left) and numbers of N nucleotides per N⁺ sequence (right) in WT (thickly hatched) and Polμ^−/− (thinly hatched) embryos. (B) Frequencies of usage of SSH⁺ DJ_H joints (left) and of ≥3-nt-long SSH (right) in WT and Polμ^−/− embryos. (C) Deleted nucleotides per DJ_H joint in WT and Polμ^−/− embryos and in newborns (a logarithmic scale is used in the x axis on the left). The arrows indicate the mean values for each group. The distribution profiles of DJ_H joints related to the extents of nucleotide deletions in WT and Polμ^−/− embryos and in WT newborns as defined by Gaussian kernel density estimations are shown in the right histograms (a linear scale is used in the x axis). The vertical lines delimit the highly preserved DJ_Hs (≤2 deleted nucleotides). (D) Frequencies of highly preserved DJ_H joints detected in perinatal pre-B/B, adult B1, and adult pre-B/B cells from healthy mice in an extensive literature review (n = 1,572 DJ_H joints from 27 series in 19 papers). Each bar corresponds to an independent series of DJ_Hs. The numbers above the bars refer to the original articles, which are listed in Table S2 in the supplemental material. The horizontal lines denote the mean of each group.