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. 2008 Dec 22;29(5):1123–1133. doi: 10.1128/MCB.00841-08

FIG. 2.

FIG. 2.

The majority of estrogen-regulated promoters are preloaded with Pol II prior to E2 treatment. (A) Gene expression microarray analysis in MCF-7 cells with (+) or without (−) E2 (3 h). (B) ChIP-chip analyses for Pol II at the promoters of all E2-regulated genes in MCF-7 cells ± E2 (45 min). (C) Heat maps of ChIP-chip for Pol II at the promoters of E2-stimulated and E2-repressed genes with (+) or without (−) E2 (45 min). (D) Averaging of Pol II promoter ChIP-chip signals for three classes of E2-stimulated genes with (+) or without (−) E2 (45 min).