Table 4.
All-cause mortality and mortality from cardiovascular disease according to categories of longitudinal GGT-change in 43,748 women, VHM&PP 1985-2005
| Longitudinal GGT-change |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Decrease |
Stable | Increase |
|||||||
| Pronounced n=6251 |
Moderate n=6253 |
Mild n=6250 |
n=6252 | Mild n=6251 |
Moderate n=6253 |
Pronounced n=6238 |
|||
| Longitudinal 7-year GGT-change (U/L) - Range |
<(-4.50) | -4.49-(-1.98) | -1.97-(-0.56) | -0.55-0.79 | 0.80-2.27 | 2.28-5.15 | >5.15 | ||
| Longitudinal 7-year GGT-change - mean±SD (median) (U/L) |
-15.4±27.0 (-8.2) | -3.1±0.7 (-3.0) | -1.2±0.4 (-1.2) | 0.1±0.3 (0.0) | 1.5±0.4 (1.4) | 3.5±0.9 (3.4) | 19.3±32.1 (9.9) | p for trend GGT decrease* |
p for trend GGT increase* |
| Baseline GGT - mean±SD (median) (U/L) |
49.4±55.9 (34.0) | 21.4±10.7 (19.7) | 18.1±8.6 (16.1) | 16.6±7.4 (14.3) | 16.1±8.3 (14.3) | 16.9±10.7 (14.3) | 26.6±26.6 (19.7) | ||
| ALL-CAUSE MORTALITY | |||||||||
| Fatal events - no.(%) | 512 (8.2) | 331 (5.3) | 246 (3.9) | 240 (3.8) | 239 (3.8) | 258 (4.1) | 421 (6.7) | ||
| HR (95% CI)† | 0.99 (0.83-1.18) | 1.03 (0.87-1.22) | 0.96 (0.80-1.15) | 1.00 (Ref) | 1.03 (0.86-1.24) | 1.14 (0.95-1.37) | 1.26 (1.06-1.49) | 0.72 | 0.003 |
| TOTAL CVD MORTALITY | |||||||||
| Fatal events - no.(%) | 214 (3.4) | 153 (2.4) | 113 (1.8) | 117 (1.9) | 114 (1.8) | 106 (1.7) | 152 (2.4) | ||
| HR (95% CI)† | 0.91 (0.70-1.19) | 0.97 (0.75-1.26) | 0.85 (0.64-1.13) | 1.00 (Ref) | 1.02 (0.78-1.34) | 1.13 (0.86-1.48) | 1.18 (0.91-1.51) | 0.91 | 0.23 |
| CORONARY HEART DISEASE | |||||||||
| Fatal events - no.(%) | 103 (1.6) | 74 (1.2) | 44 (0.7) | 50 (0.8) | 53 (0.8) | 53 (0.8) | 65 (1.0) | ||
| HR (95% CI)† | 1.15 (0.77-1.73) | 1.24 (0.84-1.84) | 0.81 (0.51-1.27) | 1.00 (Ref) | 1.24 (0.81-1.88) | 1.32 (0.87-2.00) | 1.42 (0.96-2.10) | 0.33 | 0.06 |
| CONGESTIVE HEART FAILURE | |||||||||
| Fatal events - no.(%) | 19 (0.3) | 15 (0.2) | 10 (0.2) | 15 (0.2) | 10 (0.2) | 11 (0.2) | 17 (0.3) | ||
| HR (95% CI)† | 0.77 (0.34-1.74) | 0.62 (0.27-1.45) | 1.01 (0.46-2.21) | 1.00 (Ref) | 0.78 (0.33-1.85) | 1.12 (0.50-2.49) | 1.06 (0.46-2.21) | 0.87 | 0.99 |
| STROKE | |||||||||
| Fatal events- no.(%) | 59 (0.9) | 36 (0.6) | 40 (0.6) | 30 (0.5) | 33 (0.5) | 26 (0.4) | 42 (0.7) | ||
| HR (95% CI)† | 0.69 (0.41-1.11) | 0.71 (0.43-1.16) | 0.92 (0.57-1.49) | 1.00 (Ref) | 0.79 (0.47-1.31) | 0.92 (0.56-1.51) | 0.91 (0.57-1.46) | 0.14 | 0.70 |
Log-linear trends across categories of increasing or decreasing GGT, in respect to stable GGT, were tested using the median GGT-change for each category as an ordinal variable in an extended Cox proportional hazards model adjusted for age, body-mass-index, smoking status, occupational status, triglycerides, total cholesterol, systolic and diastolic blood pressure and blood glucose as time-varying covariates. All models are additionally adjusted for baseline GGT and the period of GGT-change assessment. GGT and triglycerides were log-transformed.
Estimated extended Cox proportional hazards models adjusted for age, body-mass-index, smoking status, occupational status, triglycerides, total cholesterol, systolic and diastolic blood pressure and bloodfrom glucose as time-varying covariates. All models are additionally adjusted for baseline GGT and period of GGT-change assessment. GGT and triglycerides were log-transformed.