Table 3.
Michaelis-Menten constant values (in mM) for the three isoforms
| Number of Parameters | A Isoform | B Isoform | F Isoform | |||
|---|---|---|---|---|---|---|
| Na+ | ||||||
| 5 | 2.9 | 3.1 | 14.7 | |||
| 6 | 2.8 | 3.2 | 14.7 | |||
| 7 | 2.8 | 3.3 | 14.7 | |||
| 8 | 2.8 | 3.2 | 14.7 | |||
| Published value | 5.0±3.9 | 3.0±0.6 | 20.6±7.2 | |||
| Recomputed value | 3.0±0.8 | 3.2±0.9 | 14.3±4.6 | |||
| Cl− | ||||||
| 5 | 37.4 | 23.0 | 77.2 | |||
| 6 | 37.1 | 22.7 | 77.2 | |||
| 7 | 37.2 | 22.6 | 77.3 | |||
| 8 | 37.1 | 23.0 | 78.3 | |||
| Published value | 22.2±4.8 | 11.6±0.7 | 29.2±2.1 | |||
| Recomputed value | 37.6±21.6 | 22.8±2.7 | 79.4±55.4 | |||
| K+ | ||||||
| 5 | 1.0 | 1.0 | 3.7 | |||
| 6 | 1.1 | 1.1 | 3.7 | |||
| 7 | 1.1 | 1.1 | 3.7 | |||
| 8 | 1.1 | 1.0 | 3.5 | |||
| Published value | 0.96±0.16 | 0.76±0.07 | 1.54±0.16 | |||
| Recomputed value | 1.0±0.5 | 1.0±0.2 | 3.1±1.6 | |||
Values with 5–8 parameters were obtained from the model. Published values were reported by Plata et al. (13). Recomputed values were estimated by nonlinear fitting of the Hill equation.