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Rp-cAMP, a PKA inhibitor, does not block the inhibitory effect of 1,2-s,n-dioctanoylglycerol (DOG), a PKC activator, on phosphate transport. Sodium-dependent phosphate uptake was measured in cultured renal proximal tubule cells (n = 6) under control conditions, in the presence of DOG (10 μM), Rp-cAMP (100 μM), and DOG plus Rp-cAMP. Results are the mean of means of triplicate determinations ± SE.
