Table 2. Description of polymorphisms genotyped in the study.
| rs number | Gene region | Position 1 | Allele | MAF 2 (%) |
|---|---|---|---|---|
| IL-4 | ||||
| rs2243248 | Promoter | -1098 | T/G | 6.6 |
| rs2070874 | 5′UTR | 338 | C/T | 12.9 |
| IL-4R | ||||
| rs1805010 | Exon5, nonsynonymous | 75 3 | Ile/Val | 48.4 |
| rs1801275 | Exon11, nonsynonymous | 576 3 | Gln/Arg | 20.5 |
| IL-6 | ||||
| rs2069827 | Promoter | -1426 | G/T | 11.1 |
| rs1800797 | Promoter | -661 | A/G | 41.0 |
| rs1800795 | Promoter | -237 | G/C | 41.2 |
| rs1554606 | Intron 3 | 1825 | C/A | 47.1 |
| rs2069849 | Exon5, synonymous | 201 3 | Phe/Phe | 3.1 |
| rs2069861 | 3′UTR | 4772 | C/T | 11.2 |
| rs1818879 | 3′UTR | 5845 | G/A | 32.9 |
| IL-6R | ||||
| rs4845617 | 5′UTR | -208 | G/A | 37.1 |
| rs12083537 | Intron 1 | 2963 | T/C | 19.6 |
| rs4075015 | Intron 1 | 11090 | T/A | 41.9 |
| rs6684439 | Intron 1 | 17733 | C/T | 38.8 |
| rs4845618 | Intron 1 | 21909 | A/C | 44.0 |
| rs4845622 | Intron 6 | 33313 | T/G | 39.5 |
| rs8192284 | Exon 9, nonsynonymous | 358 3 | Asp/Ala | 39.2 |
| rs4329505 | Intron 9 | 54314 | T/C | 17.3 |
| rs4240872 | Intron 9 | 58089 | A/G | 22.6 |
| rs2229238 | 3′UTR | 59790 | G/A | 19.3 |
| IL-10 | ||||
| rs1800890 | Promoter | -3584 | T/A | 39.0 |
| rs1800896 | Promoter | -1116 | A/G | 45.3 |
| rs1800871 | Promoter | -853 | C/T | 23.8 |
| rs1800872 | Promoter | -626 | C/A | 23.0 |
1
Relative to the translation start point.
2
MAF: minor allele frequency in the controls.
3
Amino acid position