Fig. 1.
Mean arterial pressure (A) and vascular (aorta) preproendothelin-1 mRNA expression (B) in wild-type (WT) mice infused with vehicle (WT + vehicle) and TNF-α-infused WT mice (WT + TNF-α) and IL-10-knockout (IL-10−/−) mice infused with vehicle (IL-10−/− + vehicle) and TNF-α-infused IL-10−/− mice (IL-10−/− + TNF-α). Values are means ± SE (n = 5 experiments). *P < 0.05 vs. respective control (i.e., vehicle). †P < 0.05, IL-10−/− vs. WT.