Table 2.

Body weight and left ventricular morphology and fibrosis

	Con + Veh	Con + Dia	HF + Veh	HF + Dia	Wes + Veh	Wes + Dia
Body weight, g	525±21	270±15*	608±26†	314±15*	620±25†	341±18*
TL, mm	50.9±0.6	46.7±0.8*	51.2±0.5	47.9±0.5*	51.3±0.6	48.7±0.3*
Heart wt/TL, mg/mm	26.2±0.7	19.6±0.8*	27.6±1.4	22.9±1.0*	28.2±0.7	25.8±1.3‡
LV wt/TL, mg/mm	18.7±0.6	13.6±0.5*	19.4±0.7	16.0±0.8*	19.6±0.4	17.6±0.7*‡
PWd, mm	2.1±0.1	2.1±0.2	2.2±0.1	2.0±0.1	2.1±0.1	1.9±0.1
LVEDD, mm	7.5±0.3	6.8±0.2	7.8±0.1	7.8±0.4‡	7.1±0.5	8.1±0.2*‡
LVEDD/PWd	3.8±0.4	3.3±0.2	3.6±0.2	3.9±0.3	3.5±0.3	4.5±0.3*‡
LVESD, mm	4.9±0.3	4.3±0.4	4.9±0.3	5.3±0.4	4.0±0.5	5.6±0.2
Myocyte CSA, μm2	432±29	481±61	422±39	405±50	401±52	334±37
Myocardial vol % collagen, % area	2.6±0.1	2.9±0.3	2.6±0.2	2.6±0.1	3.3±0.2†§	3.0±0.1

Values are means ± SE. LV, left ventricular; PWd, posterior wall thickness; LVEDD, LV end-diastolic diameter; LVESD, LV end-systolic diameter; CSA, myocyte cross-sectional area; Vol % collagen, interstitial collagen volume percentage.

^*P < 0.05 vs. respective Veh treatment;

^†P < 0.05 vs. Con + Veh;

^‡P < 0.05 vs. Con + Dia;

^§P < 0.05 vs. HF + Veh.