Table 3.
Cardiac function and arterial stiffness
| Con + Veh | Con + Dia | HF + Veh | HF + Dia | Wes + Veh | Wes + Dia | |
|---|---|---|---|---|---|---|
| Heart rate, beats/min | 289±16 | 240±11* | 307±13 | 235±9* | 308±22 | 285±11‡ |
| MAP, mmHg | 83.8±6.1 | 63.0±5.7 | 95.2±7.7 | 82.7±7.4 | 61.4±8.7† | 73.1±9.2 |
| Pulse pressure, mmHg | 27.5±1.8 | 23.1±2.0 | 30.0±2.3 | 29.0±1.8 | 29.8±2.5 | 27.0±2.5 |
| Ejection fraction, % | 67±4 | 66±6 | 65±4 | 66±4 | 71±6 | 65±4 |
| LVEDP, mmHg | 3.1±1.2 | 5.9±2.4 | 5.5±0.7 | 7.9±1.5 | 5.1±1.2 | 5.9±1.4 |
| LVESP, mmHg | 73.3±9.1 | 65.4±2.6 | 77.5±5.5 | 84.1±9.1 | 72.8±7.9 | 80.2±6.5 |
| FS, % | 34.9±2.6 | 37.1±3.6 | 36.6±3.8 | 31.9±1.7 | 42.9±5.3 | 30.6±1.9* |
| LVEDσ, kdyn/cm2 | 2.9±1.2 | 4.5±1.8 | 4.8±0.8 | 7.9±1.7* | 4.6±1.1 | 6.2±1.4 |
| dP/dtmax, mmHg/s | 5,220±839 | 3,927±330 | 5,327±689 | 4,757±624 | 6,152±1,034 | 4,999±921 |
| dP/dtmin, mmHg/s | −6,363±1,251 | −3,945±321 | −5,950±684 | −5,243±844 | −5,607±872 | −5,191±757 |
| Ees, mmHg/ml | 0.13±0.03 | 0.16±0.04 | 0.14±0.03 | 0.10±0.02 | 0.20±0.05 | 0.10±0.02 |
| Emax, mmHg/ml | 0.24±0.07 | 0.29±0.08 | 0.38±0.09 | 0.27±0.04 | 0.42±0.12 | 0.20±0.04 |
Values are means ± SE. MAP, mean arterial pressure; LVEDP, LV end-diastolic pressure; LVESP, LV end-systolic pressure; FS, fractional shortening; LVEDσ, LV end-diastolic wall stress; dP/dtmax and dP/dtmin, maximal and minimal change in pressure over time, respectively; Ees, end-systolic volume elastance; Emax, maximal elastance.
*
P < 0.05 vs. respective Veh treatment;
†
P < 0.05 vs. HF + Veh;
‡
P < 0.05 vs. HF + Dia.