Table 1.
Alterations in MAP, HR, ±dP/dt, and Hb at 2 h after T-H and resuscitation
| Sham-V | Sham-G | TH-V | TH-G | |
|---|---|---|---|---|
| MAP, mmHg | 126.8±2.7 | 122.6±1.8 | 46.7±8.4* | 81.5±4.4† |
| HR, beats/min | 408.8±2.6 | 406.0±65 | 277.3±19.5* | 386.1±15.0† |
| +dP/dt, mmHg/s | 16,910±2,108 | 17,063±328 | 6,388±745* | 11,619±712† |
| −dP/dt, mmHg/s | 9,323±976 | 10,572±248 | 3,668±1,203* | 6,593±402† |
| Hb, g/dl | 14.2±0.4 | 14.3±0.5 | 6.7±0.2* | 5.8±0.4* |
| Hct, % | 42.4±1.7 | 43.9±1.4 | 21.0±0.5* | 18.4±1.2* |
| Lactate, mg/dl | 10.2±0.5 | 6.8±0.7 | 73.4±17.3* | 10.8±1.4† |
Values are means ± SE (n = 5 rats/group). Sham-V, sham-operated rats (with vehicle); sham-G, sham-operated rats plus glucosamine; TH-V, trauma-hemorrhage (TH) treated with vehicle; TH-G, TH treated with glucosamine; MAP, mean arterial blood pressure; HR, heart rate; +dP/dt, maximum change of pressure over time; −dP/dt, minimum change of pressure over time; Hb, hemoglobin; Hct, hematocrit. Values were compared by one-way ANOVA and Tukey's test:
*
P < 0.05 vs. sham-V;
†
P < 0.05 vs. TH-V.