Fig. 7.

Schematic representation of regulation of PAI-2 expression by gastrin. Gastrin regulates PAI-2 expression in both CCK-2 receptor-expressing cells by acting directly through its receptor (left) and in neighboring cells, via paracrine mediators released from CCK-2 receptor expressing cells (right). Direct regulation involves the CRE and AP-1 sites via PKC, Ras, Raf, RhoA, and the NF-κB pathways. The paracrine mediators IL-8 and PGE₂ are released in response to gastrin stimulation; IL-8 acts through a GACAGA site via the ASC-1 complex, whereas PGE₂ targets the MAZ site via the small GTPase RhoA.