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Cotransfer of CD11a−/− regulatory T cells (Tregs; CD4+CD25+) with CD4+CD45RBhigh T cells suppresses the development of chronic colitis as effectively as wild-type Tregs. Wild-type or CD11a−/− Tregs (0.25 × 106 cells) were injected into RAG−/− recipients at 2 wk following injection of CD4+CD45RBhigh T cells (0.5 × 106 cells). Histopathology was quantified at 8 wk posttransfer.
