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A: indomethacin [a nonselective cyclooxygenase (COX) inhibitor] produces a concentration-dependent and significant decrease in internal anal sphincter (IAS) tone in rats; solvent vehicle (Na2CO3) has no significant effect (P > 0.05). Values are means ± SE (n = 9). *P < 0.05. B: an actual tracing of the effect of 10 μM indomethacin.
