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A: RT-PCR products of genomic DNA from COX-1- and COX-2-knockout (COX-1−/− and COX-2−/−) and wild-type [WT (COX-1+/+ and COX-2+/+)] mice. B: IAS from COX-1−/− mice developed significantly lower basal tone than IAS from WT mice. C: there were no significant differences in IAS tone between WT and COX-2−/− mice (P > 0.05). Values are means ± SE (n = 5). *P < 0.05.
