Table 1.

Alignment of the NH₂ termini of 5 mammalian ATP7B sequences

human-----------MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVR	63
rat-----------MPEQERKVTAKE-ASRKILSKLALPTRPWGQSMKQSFAFD NVGYEGGLDSTC-SSSTTTGVVS	62
mouseMDPRKNLASVGTMPEQERQVTAKE-ASRKILSKLALPGRPWEQSMKQSFAFD NVGYEGGLDSTS-SSPAATDVVN	74
dog----------------------------------------MKQSFAFD NVGYEGGLDSVC-PPQTATSTIS	31
sheep----------MKPEEERPIIDREKASRRILSKLFQP------AMKQSFAFD NNGYEDDLDGVC-PSQTAAGTIS	58
★★★★★★★★ ★★★★★★★★★★★★★★★★★★★★★★

Summary of mutagenesis/trafficking results of residues 37–45 in NH₂ terminus of ATP7B. Residues that are underlined were chosen for mutagenesis.