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G298S mutation reduces Na+ current density at multiple holding voltages. Peak Na+ current densities sorted by holding voltage and recorded from HEK cells expressing SCN5A transcript backgrounds H558/Q1077del (A, n = 14–30), H558R/Q1077del (B, n = 9–17), H558/Q1077 (C, n = 5–10), or H558R/Q1077 (D, n = 5–10) with the G298 wild-type allele or the G298S missense mutation are shown. *P < 0.05.
