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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: J Immunol. 2008 Sep 15;181(6):4272–4278. doi: 10.4049/jimmunol.181.6.4272

FIGURE 6.

FIGURE 6

Cytokine concentrations in the supernatants of activated T cells. A, Purified RAGE−/− (solid bars) and WT (stippled bars) T cells were activated with anti-CD3 and anti-CD28 mAbs and the culture supernatants were harvested for measurement of cytokine concentrations (mean ± SEM, n = 4/group). There was a significant increase in the concentration of TNF-α, IL-5, and IL-10 in the cultures from RAGE−/− mice compared with WT mice (*, p < 0.05; **, p < 0.01). B, Primary MLR’s with purified WT T cells were cultured in the presence of TTP488 or the excipient DMSO as described. The responders were harvested after 5 days and activated with PMA/ionomycin overnight. The concentrations in the supernatants were measured (n = 3/group). There was a significant reduction in the production of IFN-γ in responders that had been cultured with TTP488.