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The effects of ANG II on blood-derived T cell production of TNF-α. T cells were isolated by negative selection, and 2 × 105 cells were placed in culture for 48 h. A: effect of exogenous ANG II on TNF-α production in circulating T cells. B: effect of the ANG I-converting enzyme inhibitor perindopril. The addition of ANG II restored the decrease in production of TNF-α caused by perindopril (n = 7). *P < 0.01 vs. control cells.
