Table 3.
Urinary volume, urinary and plasma Na+ and K+ concentrations in female sheep before and after Na+ load and Na+ load with ANG-(1-7) infusion
| Baseline |
Na Load | Post-Na+ Load (1 h) | ||||
|---|---|---|---|---|---|---|
| Vehicle | Β | Vehicle | β | Vehicle | β | |
| VUrine, ml/h | ||||||
| Control | 99.7±9.2 | 77.6±9.9 | 137.6±23.4† | 97.4±11.0† | 150.9±21.8† | 116.0±17.0† |
| ANG-(1-7) | 142.6±22.9* | 164.7±29.1* | 191.6±34.0*† | 244.6±29.5*† | 171.0±23.9† | 206.7±25.5*† |
| [Na+]Urine, mmol/l | ||||||
| Control | 182.6±24.0 | 180.1±31.8 | 190.3±16.7 | 236.4±27.2 | 257.0±23.3‡ | 272.3±24.2‡ |
| ANG-(1-7) | 187.6±31.3 | 176.1±18.9 | 192.7±30.9 | 193.2±20.9 | 213.2±25.6 | 193.4±19.8 |
| [K+]Urine, mmol/l | ||||||
| Control | 181.1±24.0 | 156.0±27.5 | 192.3±30.8 | 149.0±28.9 | 178.6±30.3 | 143.8±30.2 |
| ANG-(1-7) | 159.8±22.6 | 151.7±22.9 | 154.4±25.6 | 150.3±25.0 | 120.1±18.1 | 155.0±19.3 |
| [Na+]Plasma, mmol/l | ||||||
| Control | 151.4±3.7 | 149.2±1.8 | 153.2±3.4 | 146.1±4.2 | 148.1±3.7 | 149.1±1.9 |
| ANG-(1-7) | 151.9±3.0 | 149.0±4.2 | 151.5±2.1 | 155.8±5.0 | 148.7±2.9 | 152.3±2.5 |
| [K+]Plasma, mmol/l | ||||||
| Control | 4.03±0.08 | 4.12±0.14 | 4.08±0.13 | 3.95±0.14 | 4.22±0.14 | 4.14±0.07 |
| ANG-(1-7) | 4.13±0.07 | 4.29±0.09 | 4.15±0.10 | 4.33±0.11 | 4.03±0.15 | 4.26±0.18 |
Values are means ± SE; n = 6-9 sheep.
*
F = 11.0, P = 0.005, control vs. ANG-(1-7).
†
F = 5.0, P = 0.014, baseline versus later times, both groups.
‡
F =7.5, P = 0.003, baseline vs. later times, both groups.