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Schematic representation of proposed mitochondrial regulation of vascular tone in cerebral arteries. ×, Potential sites of interruption in the pathways leading to impaired mitochondria-dependent vasodilation in ZO arteries; dashed arrows, pathways that have not been resolved. ER, endoplasmic reticulum; SR, sarcoplasmic reticulum; PGs, prostaglandins; KATP channels, ATP-sensitive K+ channels; IR, insulin-resistant; SDH, succinate dehydrogenase; [Ca2+], Ca2+ concentration.
