Table 2.

Bacteria, ¹³¹I-albumin, and edema in the instilled lung

Macrophages	Pretreatment	Bacteria in Lungs*	131I in Air Space, %†	W/D Ratio‡
Normal	Vehicle	9.44±0.09	0.45±0.06	11.01±0.41
	IL-10	9.38±0.07	0.49±0.05	10.43±0.49
Depleted	Vehicle	9.45±0.04	0.51±0.08	10.11±0.70
	IL-10	9.51±0.17	0.56±0.04	10.24±0.43

Data are shown as means ± SE. Lungs were removed 8 h after the bacterial instillation.

^*The bacteria in the infected lung were assessed by determining the number of bacteria in the lung homogenate. The data shown represent the log₁₀[colony-forming units (CFU)/g tissue].

^†Lung endothelial permeability was assessed by the influx of the vascular protein tracer (¹³¹I-albumin) into the air spaces.

^‡Lung edema was measured as the lung wet-to-dry weight (W/D) ratio. There were no statistical differences between treatments. ¹³¹I in air space for uninfected rabbits (n = 4) ventilated for 8 h was 0.24% ± 0.10%, and W/D of right lung of uninfected rabbits (n = 4) ventilated for 8 h was 6.42 ± 0.44.